Study of the influence of emotion stress on mechanical hyperalgesia of masseter muscles in rats / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the influence of emotion stress on mechanical hyperalgesia of masseter muscles in rats through the equipment of communication box.</p><p><b>METHODS</b>50 Sprague-Dawley rats were randomly divided into 5 groups Control group, emotion stress (ES) group, drug control group, saline treated control group and footshock (FS) group, 10 rats each group. Footshock group only induced emotion stress and was not concerned with the result of the experiment. The last four groups of the rats were placed in communication box and bred under the same conditions during the experiment time. According to Rens' method, von Frey filaments were used to assess the muscle mechanical threshold, head withdrawal, leg raising and crying were observed as pain action.</p><p><b>RESULTS</b>1) During the adaptive period of 7 days before the emotion stress experiment, mechanical pain values of bilateral masseter muscles were descent and were stabilized in the 5 th to 7 th day. In emotion stress period, hyperalgesia of emotion stress group was induced in bilateral masseter muscles, and the peak time was the 7 th day, then it alleviated in the following days and was stabilized in the 12 th to 14 th day, but its pain threshold was lower than blank control group. 2)During the emotion stress period, the change of drug control group was similar to stress group but its pain threshold was higher.</p><p><b>CONCLUSION</b>It is suggested that emotion stress can lead to the hyperalgesia of masseter muscles and antidepressant drug can lower the hyperalgsia resulted of emotion stress.</p>