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Multicenter Evaluation of the Molecular Line Probe Assay for Multidrug Resistant Mycobacterium Tuberculosis Detection in China / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 464-467, 2015.
Artículo en Inglés | WPRIM | ID: wpr-264560
ABSTRACT
In order to evaluate the performance of a molecular Hain line probe assay (Hain LPA) for rapid detection of rifampicin and isoniazid resistance of Mycobacterium tuberculosis in China, 1612 smear positive patients were consecutively enrolled in this study. Smear positive sputum specimens were collected for Hain LPA and conventional drug susceptibility testing (DST). The sensitivity and specificity of Hain LPA were analyzed by using conventional DST as golden reference. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for rifampicin resistance detection were 88.33%, 97.66%, 81.54%, and 98.62%, respectively. The sensitivity, specificity, PPV and NPV for isoniazid resistance detection were 80.25%, 98.07%, 87.25%, and 96.78%, respectively. These findings suggested that Hain LPA can be an effective method worthy of broader use in China.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Rifampin / China / Tuberculosis Resistente a Múltiples Medicamentos / Diagnóstico / Técnicas de Genotipaje / Genética / Isoniazida / Métodos / Microbiología Tipo de estudio: Estudio diagnóstico / Estudio pronóstico Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Biomedical and Environmental Sciences Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Farmacología / Rifampin / China / Tuberculosis Resistente a Múltiples Medicamentos / Diagnóstico / Técnicas de Genotipaje / Genética / Isoniazida / Métodos / Microbiología Tipo de estudio: Estudio diagnóstico / Estudio pronóstico Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Biomedical and Environmental Sciences Año: 2015 Tipo del documento: Artículo