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Therapeutic potential of extracellular ATP and P2 receptors in nervous system diseases / 神经科学通报·英文版
Neuroscience Bulletin ; (6): 27-32, 2009.
Artículo en Inglés | WPRIM | ID: wpr-264644
ABSTRACT
Extracellular adenosine 5 inch-triphosphate (ATP) is a key signaling molecule present in the central nervous system (CNS), and now is receiving greater attention due to its role as a messenger in the CNS during different physiological and pathological events. ATP is released into the extracellular space through vesicular exocytosis or from damaged and dying cells. Once in the extracellular environment, ATP binds to the specific receptors termed P2, which mediate ATP effects and are present broadly in both neurons and glial cells. There are P2X, the ligand-gated ionotropic receptors, possessing low affinity for ATP and responsible for fast excitatory neurotransmission, and P2Y, the metabotropic G-protein-coupled receptors, possessing high affinity for ATP. Since massive extracellular release of ATP often occurs after stress, brain ischemia and trauma, the extracellular ATP is considered relating to or involving in the pathological processes of many nervous system diseases. Conversely, the trophic functions have also been extensively described for the extracellular ATP. Therefore, extracellular ATP plays a very complex role in the CNS and its binding to P2 receptors can be related to toxic and/or beneficial effects. In this review, we described the extracellular ATP acting via P2 receptors as a potent therapeutic target for treatment of nervous system diseases.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fisiología / Adenosina Trifosfato / Receptores Purinérgicos P2 / Líquido Extracelular / Usos Terapéuticos / Quimioterapia / Metabolismo / Enfermedades del Sistema Nervioso Límite: Animales / Humanos Idioma: Inglés Revista: Neuroscience Bulletin Año: 2009 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fisiología / Adenosina Trifosfato / Receptores Purinérgicos P2 / Líquido Extracelular / Usos Terapéuticos / Quimioterapia / Metabolismo / Enfermedades del Sistema Nervioso Límite: Animales / Humanos Idioma: Inglés Revista: Neuroscience Bulletin Año: 2009 Tipo del documento: Artículo