Determination of plasma protein binding rate of methyl protodioscin with ultrafiltration / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1291-1294, 2008.
Article
en Zh
| WPRIM
| ID: wpr-264920
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the plasma protein binding rate of methyl protodioscin.</p><p><b>METHOD</b>The ultrafiltration was employed to determine the plasma protein binding rate of methyl protodioscin. The plasma concentrations of methyl protodioscin were measured by HPLC-MS-MS.</p><p><b>RESULT</b>The plasma protein binding rate of methyl protodioscin with rat plasma at the concentration of 20.0, 100 and 200 microg x mL(-1) were (94.6 +/- 0.16)%, (91.6 +/- 0.35)% and (86.10 +/- 0.60)%, respectively, while the plasma protein binding rate of methyl protodioscin with normal human plasma at the above concentrations were (82.11 +/- 5.12)%, (84.54 +/- 0.32)% and (88.52 +/- 1.02)%, respectively.</p><p><b>CONCLUSION</b>The binding rate of methyl protodioscin with plasma protein is high.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Unión Proteica
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Saponinas
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Calibración
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Proteínas Sanguíneas
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Ultrafiltración
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Cromatografía Líquida de Alta Presión
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Sensibilidad y Especificidad
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Diosgenina
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Espectrometría de Masas en Tándem
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Metabolismo
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
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Female
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Humans
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Male
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2008
Tipo del documento:
Article