Research progress on B lymphocyte-induced maturation protein 1 and its relationship with the development of lymphoma / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1623-1626, 2013.
Artículo
en Chino
| WPRIM
| ID: wpr-264964
ABSTRACT
Many studies show that as a transcription factor, B lymphocyte-induced maturation protein 1 (Blimp 1) is the master regulator of plasma-cell differentiation. The abnormality of Blimp 1 plays an important part in the genesis and development of lymphoma. This review introduces and summarizes Blimp 1's protein structure and functions, its role in B cell differentiation, its main target genes and the mechanism of its transcriptional repressor activity. Besides, the relationship between Blimp 1 gene mutation or Blimp 1 protein expression reduction and the development of DLBCL is preliminary summaried.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteínas Represoras
/
Factores de Transcripción
/
Linfocitos B
/
Diferenciación Celular
/
Linfoma de Células B Grandes Difuso
/
Antígeno de Maduración de Linfocitos B
/
Factor 1 de Unión al Dominio 1 de Regulación Positiva
/
Genética
/
Metabolismo
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2013
Tipo del documento:
Artículo
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