Effect of the polymorphism of myeloperoxidase gene on the risk of benzene poisoning / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 86-89, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-265050
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between the polymorphism myeloperoxidase (MPO) gene and the genetic susceptibility to benzene toxicity in workers exposed to benzene and in patients with benzene poisoning.</p><p><b>METHODS</b>Using polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) techniques, the genotypes' polymorphism of MPO gene in 35 patients with chronic benzene poisoning, 46 workers exposed to benzene from the same workplace (as exposed control) and 26 controls were analyzed.</p><p><b>RESULT</b>There were three (G/G, G/A and A/A) genotypes in the region of 463 bp upstream of MPO gene. The distribution frequency in G/G wild-type genotype in patients was 27.4% more than that in the exposed workers. The risk of benzene-hematotoxicity in those with G/G genotype was 2.8-fold higher than G/A + A/A genotype (OR = 2.835, 95% CI 1.065 - 7.549, P < 0.05). The polymorphism of myeloperoxidase was not associated with gender specific.</p><p><b>CONCLUSION</b>In the same benzene-exposed environment, the subjects with MPO-463 G/G genotype may be more susceptible to benzene toxicity.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Intoxicación
/
Polimorfismo Genético
/
Benceno
/
Riesgo
/
Exposición Profesional
/
Peroxidasa
/
Genética
/
Genotipo
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Año:
2003
Tipo del documento:
Artículo
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