Molecular genetic studies on ganglioglioma / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 147-149, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-265168
ABSTRACT
<p><b>OBJECTIVE</b>To study the genetic alterations of ganglioglioma through the entire genome, and to investigate the pathogenesis of this neoplasm.</p><p><b>METHODS</b>Comparative genomic hybridization was used to provide an overview of genetic abnormalities in gangliogliomas.</p><p><b>RESULTS</b>Five cases of gangliogliomas, including 3 males and 2 females, were studied genetically. Loss of genetic materials on the short arm of chromosome 9(9p) was a common genetic alteration found in 3 of 5 cases. Overrepresentation of chromosome 7 was another recurrent chromosomal imbalance, which was further confirmed by fluorescence in situ hybridization. Immunohistochemical analysis was performed on epidermal growth factor receptor (EGFR), which was located on 7p11-p13. All five cases revealed no abnormal expression of EGFR. On the other hand, genetic imbalances were also involved in multiple chromosomes including 2q33-q34, 8q12-q22, 14q21-qter, 15q26-qter and Y.</p><p><b>CONCLUSION</b>Loss of genetic materials on chromosome 9p and gain on chromosome 7 may be associated with the pathogenesis of this neoplasm.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Cromosomas Humanos Par 7
/
Cromosomas Humanos Par 9
/
Neoplasias Encefálicas
/
Estudios de Seguimiento
/
Aberraciones Cromosómicas
/
Deleción Cromosómica
/
Hibridación Fluorescente in Situ
/
Ganglioglioma
/
Receptores ErbB
/
Genética
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Pathology
Año:
2005
Tipo del documento:
Artículo
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