Study on preparation and release mechanism of effervescent osmotic pump tablet of compound Danshen / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 848-851, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-265356
ABSTRACT
<p><b>OBJECTIVE</b>To prepare effervescent osmotic pump tablet (EOPTs) according to the rhythm of coronary heart disease based on efficacy material and the mechanism of compound Danshen and to study the mechanism of drug released of that tablets.</p><p><b>METHOD</b>Since compound Danshen consist of compounds with polyphenolic groups or carboxyl groups, such as phenolic acids, flavonoids, and triterpenoids that they were acidic. EOPTs were prepared from tablet cores which containing NaHCO3 as effervescent, NaCL and manitol as osmotic agents, HPMC as retarding agents coating with CA membrane. And study the mechanism of drug released according to the change of tablet osmotic pressure.</p><p><b>RESULT</b>The results of in vitro experiments showed that no difference was observed among the profiles of Danshensu, protocatechuic aldehyde, ginsenoside Rg1, Rb1, notoginsenoside R1 release EOPTs. The drug was completely released from the device with a zero-order release rate over 12 h.</p><p><b>CONCLUSION</b>EOPTs are Successfully obtained EOPT which the drug is released from the device over 12 h and the release mechanism of EOPTs is explained.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ósmosis
/
Comprimidos
/
Factores de Tiempo
/
Bombas de Infusión
/
Medicamentos Herbarios Chinos
/
Enfermedad Coronaria
/
Salvia miltiorrhiza
/
Composición de Medicamentos
/
Metabolismo
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2009
Tipo del documento:
Artículo
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