Evaluation of nasal absorption for geniposide solution / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 839-842, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-265358
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the regulation of geniposide nasal absorption.</p><p><b>METHOD</b>We used rat in situ nasal recirculation method as experimental model. The effects of perfusion volume, flow rate, perfusion concentration on nasal absorption of geniposide were studied.</p><p><b>RESULT</b>Geniposide was stable in rats nasal lavage solution. At the perfusion volume 5 mL and flow rate 2.5 mL x min(-1), the absorption rate of geniposide remains constant in a dose-independent manner.</p><p><b>CONCLUSION</b>The mechanism of geniposide nasal absorption is passive diffusion following first order kinetics and the absorption rate constant is 4.20 x 10(-3).</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Perfusión
/
Soluciones
/
Administración Intranasal
/
Medicamentos Herbarios Chinos
/
Cinética
/
Modelos Lineales
/
Nariz
/
Sensibilidad y Especificidad
/
Iridoides
/
Difusión
Tipo de estudio:
Estudio diagnóstico
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2009
Tipo del documento:
Artículo
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