Oligomeric interaction between ryanodine receptors: potential role in Ca(2+) release / 生理学报
Acta Physiologica Sinica
;
(6): 305-308, 2006.
Artículo
en Inglés
| WPRIM
| ID: wpr-265451
ABSTRACT
Receptor proteins in both eukaryotic and prokaryotic cells often form regular lattice or array in the membrane. Recent theoretical analyses indicate that such arrays may provide a novel mechanism for receptor signaling regulation in cells. The functional coupling between neighboring receptors could improve the signaling performance. The ryanodine receptors (RyR)/calcium release channels usually form 2-D regular lattice in the endoplasmic/sarcoplasmic reticulum membranes. Thus, RyR is a potentially good model to study the function of receptor 2-D array. In this article, we briefly review recent progresses in this research field, including RyR-RyR interaction, RyR array's function and working mechanisms. The investigations performed by new methods in our laboratory are summarized. We demonstrate that the RyR-RyR interaction is modulated by the functional states of RyRs. Accordingly, the mechanism of "dynamic coupling" of RyR array is proposed. Its possible role in RyR-mediated Ca(2+) release is discussed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Retículo Sarcoplasmático
/
Cationes
/
Calcio
/
Músculo Esquelético
/
Canal Liberador de Calcio Receptor de Rianodina
/
Receptor Cross-Talk
/
Metabolismo
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Acta Physiologica Sinica
Año:
2006
Tipo del documento:
Artículo
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