Developmental regulation of intracellular calcium homeostasis in early cardiac myocytes / 生理学报

ABSTRACT

The proper intracellular Ca(2+) signaling is essential for normal cell functions and organ development, and the maintaining Ca(2+) homeostasis in cardiac myocytes is of functional importance for the intact heart. As the first functional organ in the vertebrate embryo, the heart is continuously remodeled and maintains its physiologic pumping function in response to increasing circulatory demands. The expressions of Ca(2+) handing proteins in the embryonic heart, however, are different from those in neonatal and adult hearts, which means that the regulation of Ca(2+) transients in embryonic cardiomyocytes is different from that in adult cardiac myocytes. Recent advances in molecular and cellular biology, as well as the application of embryonic stem cell differentiation system, have made progress in uncovering the regulation of Ca(2+) homeostasis during cardiomyogenesis. This paper briefly summarizes the Ca(2+) homeostasis during early development of cardiomyocytes and reviews current knowledge of the regulatory mechanisms controlling Ca(2+) homeostasis during cardiomyocyte development.