Discussion of Chinese syndrome typing in acute hepatic failure model / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 659-662, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-265836
ABSTRACT
<p><b>OBJECTIVE</b>To study Chinese syndrome typing of acute hepatic failure (AHF) mice model by screening effective formulae.</p><p><b>METHODS</b>Lipoplysaccharides (LPS)/D-galactosamine (D-GaIN) was intraperitoneally injected to mice to establish the AHF mice model. Yinchenhao Decoction, Huanglian Jiedu Decoction, Buzhong Yiqi Decoction, and Xijiao Dihuang Decoction were administered to model mice respectively by gastrogavage. The behavior and the survival rate were monitored. The liver function and pathological changes of liver tissues were detected.</p><p><b>RESULTS</b>In all the tested classic recipes, the survival rate was elevated from 10% to 60% by administration of Xijiao Dihuang Decoction. Five h after modeling, the serum alanine aminotransferase (ALT) level was (183.95 +/- 52.00) U/L, and aspartate aminotransferase (AST) (235.70 +/- 34.03) U/L in Xijiao Di-huang Decoction Group, lower than those of the model control group, but with insignificant difference (ALT 213.32 +/- 71.93 U/L; AST 299.48 +/- 70.56 U/L, both P > 0.05). Xijiao Dihuang Decoction could obviously alleviate the liver injury.</p><p><b>CONCLUSIONS</b>Xijiao Dihuang Decoction was an effective formula for LPS/D-GaIN induced AHF model. According to syndrome typing through formula effect, heat toxin and blood stasis syndrome dominated in the LPS/D-GalN induced AHF mice model.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Medicamentos Herbarios Chinos
/
Fallo Hepático Agudo
/
Diagnóstico
/
Modelos Animales de Enfermedad
/
Quimioterapia
/
Medicina Tradicional China
/
Fitoterapia
/
Ratones Endogámicos C57BL
Tipo de estudio:
Estudio diagnóstico
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Integrated Traditional and Western Medicine
Año:
2011
Tipo del documento:
Artículo
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