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Comparative study of lipophilicity from immobilized artificial chromatography and n-octanol/buffer systems / 药学学报
Acta Pharmaceutica Sinica ; (12): 791-794, 2003.
Artículo en Chino | WPRIM | ID: wpr-266601
ABSTRACT
<p><b>AIM</b>To compare lipophilicity measuring scale stemmed from immobilized artificial membrane chromatography and n-octanol/buffer systems.</p><p><b>METHODS</b>A test set consisted of 27 structurally diverse compounds. The lipophilicity of these were evaluated by both immobilized artificial membrane chromatography (IAMC) and n-octanol/buffer systems, which were expressed as lg kIAM and lg DO/W,7.4, respectively.</p><p><b>RESULTS</b>With regard to each individual group, good correlation coefficient (r2) over 0.81 was obtained (0.82 for acid; 0.88 for neutral, 0.81 for base and 0.92 for ampholyte, respectively). However, a smaller r2 (0.62) was acquired for all compounds studied than that of each individual group.</p><p><b>CONCLUSION</b>IAMC and n-octanol/buffer systems were shown to be different in lipophilicity.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fosfolípidos / Tampones (Química) / Preparaciones Farmacéuticas / Química / Cromatografía Líquida de Alta Presión / Octanoles / Interacciones Hidrofóbicas e Hidrofílicas / Lípidos / Membranas Artificiales / Métodos Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2003 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fosfolípidos / Tampones (Química) / Preparaciones Farmacéuticas / Química / Cromatografía Líquida de Alta Presión / Octanoles / Interacciones Hidrofóbicas e Hidrofílicas / Lípidos / Membranas Artificiales / Métodos Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2003 Tipo del documento: Artículo