Preparation of sustained-release nitrendipine microspheres with a solid dispersed structure in liquid system / 药学学报
Acta Pharmaceutica Sinica
;
(12): 634-638, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-266619
ABSTRACT
<p><b>AIM</b>To prepare the sustained-release nitrendipine microspheres with a solid dispersed structure in liquid system.</p><p><b>METHODS</b>The sustained-release nitrendipine microspheres with a solid dispersed structure was prepared in liquid system by combining spherical crystallization technique and solvent deposition method in one step. The resultant microspheres were evaluated for the recovery, micromeritc properties, incorporation efficiency. The factors of effect on the formation and the release rate of microspheres were also investigated.</p><p><b>RESULTS</b>The recovery of microspheres (280-900 microns) was more than 70% and the bulk density was around 0.7 kg.L-1. The incorporation efficiency always exceeded 95%. The formation of microspheres was mainly affected by the amount of bridging liquid and the emulsifying agents in poor solvent. The release rate of nitrendipine from the microspheres could be controlled as desired by adjusting the ratio of talc to Eudragit RS PO in the formulation.</p><p><b>CONCLUSION</b>The presented method was suitable for preparing sustained-release microspheres of a water insoluble drug.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tamaño de la Partícula
/
Portadores de Fármacos
/
Nitrendipino
/
Tecnología Farmacéutica
/
Preparaciones de Acción Retardada
/
Métodos
/
Microesferas
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2003
Tipo del documento:
Artículo
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