Advances in molecular mechanisms of tenascin-C in promoting tumor metastasis / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 240-244, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-266692
ABSTRACT
Tenascin-C (TNC) is an extracellular matrix glycoprotein, which is usually highly expressed in embryonic tissues and tumor tissues, but is not expressed or just lowly expressed in mature tissues. TNC is involved in various complex signaling pathways during tumor metastasis, especially through modulating FAK, RhoA, Wnt and Notch pathways by interacting with syndecan-4, integrin α5β1, matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF). As a result, TNC affects epithelial mesenchymal transition, tumor cell adhesion, proliferation and angiogenesis, which eventually enhances the invasion and metastasis ability of many tumors. Further studies have demonstrated that TNC could be used as prognosis or metastasis marker of patients with malignant tumor.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Transducción de Señal
/
Integrinas
/
Adhesión Celular
/
Tenascina
/
Metaloproteinasas de la Matriz
/
Factor A de Crecimiento Endotelial Vascular
/
Metástasis de la Neoplasia
/
Neoplasias
/
Neovascularización Patológica
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Biomedical Engineering
Año:
2015
Tipo del documento:
Artículo
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