Primary study on hepatoprotective effect of curcuminoid in mice
Journal of Medical Research
;
: 22-28, 2007.
Artículo
en Vietnamita
| WPRIM
| ID: wpr-267
ABSTRACT
Background:
Curcuminoid in crocus has a wide spectrum of therapeutic effects such as antitumor and anti-inflammatory effects, including antibacterial, antiviral, antifungal, and antispasmodic activities. Curcuminoid \ufffd?biofavonoid, a component of Cucuma longa L is attracting attention of researchers because of their effects and low toxicity.Objectives:
To evaluate the hepatoprotective effect of curcuminoid on acute liver injury induced by carbon tetraclorid (CCl4 and paracetamol (PAR) in mice.) Subjects andmethod:
Curcuminoid at doses of 60mg/kg and 120mg/kg were used in 8 consecutive days before hepatotoxins ( CCl4 0.5ml/kg in olive oil or PAR 400mg/kg) in mice.Results &Conclusion:
Curcuminoid has hepatoprotective effect, expressed by reductions of serum levels of ALT, AST and liver histopathological injuries, in comparison with the control group ( which didn\u2019t use any drug). Curcuminoid at doses of 60mg/kg and 120mg/kg have hepatoprotective effect on acute liverinjury induced by carbon tetraclorid and paracetamol in mice. Curcuminoid at two different doses and silymarin at a dose 67mg/kg. The result showed that just low dose of curcuminoid (60mg/kg in mice) was enough to protect liver. It was just cheaper and safer than using high dose when using high dose the effect was not increase much.\r\n', u'\r\n', u'
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Curcuma
/
Enfermedad Hepática Inducida por Sustancias y Drogas
Idioma:
Vietnamita
Revista:
Journal of Medical Research
Año:
2007
Tipo del documento:
Artículo
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