cDNA macroarray for analysis of gene expression profiles in prostate cancer / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 570-573, 2006.
Artículo
en Inglés
| WPRIM
| ID: wpr-267083
ABSTRACT
<p><b>BACKGROUND</b>Early diagnosis and timely treatment are important for improving therapeutic efficiency of prostate cancer. DNA array is a new bio-technology for disease diagnosis. This study was conducted to diagnose prostate cancer with cDNA macroarray and analysis gene expression profiles of some selective genes in prostate cancer.</p><p><b>METHODS</b>Total RNA was isolated from patients with prostate cancer and from normal people, and poly (A) RNA was further purified. Then it was analyzed for differentially expressed genes in prostate cancer and normal prostate by cDNA macroarray system.</p><p><b>RESULTS</b>There were different expressions in the nine prostate-associated specific genes in prostate cancer as compared with normal prostate, in which, 7 were significantly upregulated and 2 were down-regulated.</p><p><b>CONCLUSION</b>As a diagnostic approach at molecular level, the cDNA macroarray is an effectively diagnostic method for prostate cancer.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias de la Próstata
/
Sangre
/
Genes Supresores de Tumor
/
Antígeno Prostático Específico
/
Análisis de Secuencia por Matrices de Oligonucleótidos
/
Perfilación de la Expresión Génica
/
Diagnóstico
/
Genética
Tipo de estudio:
Estudio diagnóstico
/
Estudio de tamizaje
Límite:
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Chinese Medical Journal
Año:
2006
Tipo del documento:
Artículo
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