Effect of arctiin on mouse podocyte epithelial-mesenchymal transition induced by advanced oxidation protein products / 南方医科大学学报
Journal of Southern Medical University
;
(12): 379-382, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-267595
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of arctiin on mouse podocyte epithelial-mesenchymal transition (EMT) induced by advanced oxidation protein products (AOPP).</p><p><b>METHODS</b>Mouse podocytes were stimulated by 200 µg/ml AOPP for 24 h in the presence of 50, 100, 200, and 400 µmol/L arctiin. The expressions of α-smooth muscle actin, Grp78 and CHOP were detected using Western blotting.</p><p><b>RESULT</b>The expressions of α-SMA, Grp78 and CHOP were inhibited by arctiin, showing a dose-dependent effect within a given range of arctiin concentration.</p><p><b>CONCLUSION</b>AOPP causes endoplasmic reticulum stress to induce EMT of mouse podocytes, and arctiin can decrease EMT by alleviating the stress. This finding sheds light on a new scope of research of renal fibrosis.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Farmacología
/
Línea Celular
/
Actinas
/
Podocitos
/
Factor de Transcripción CHOP
/
Transición Epitelial-Mesenquimal
/
Estrés del Retículo Endoplásmico
/
Productos Avanzados de Oxidación de Proteínas
/
Furanos
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2012
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS