Relationship between spinal function and the severity of spinal cord injury by needle puncture / 南方医科大学学报
Journal of Southern Medical University
;
(12): 333-336, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-267606
ABSTRACT
<p><b>OBJECTIVE</b>To observe the changes in spinal cord pathophysiology, motor function and electrophysiology after spinal cord injuries induced by punctures with different needles, and explore a new means for studying spinal neurotoxicity of local anesthetics.</p><p><b>METHODS</b>A total of 144 SD rats were randomly allocated into the sham-operated group (n=36) and 3 spinal cord injury groups (n=36) with the L4-5 segment of the dura mater of the spinal cord punctured using 29G, 25G, and 21G needles. The BBB scores before surgery were recorded, and at 8 h, 24 h, 72 h, 1 week, and 2 weeks after the surgery, the motor evoked potential (MEP), spinal cord pathology and the BBB scores were examined.</p><p><b>RESULTS</b>In the control group, the rats showed normal BBB score, spinal function and microstructure. Spinal cord puncture with 29G needle did not cause obvious pathologies of the spinal cord, whereas puncture with 21G needle resulted in marked changes in the motor function, electrophysiology and histology of the spinal cord, which showed significant improvements at 2 weeks postoperatively.</p><p><b>CONCLUSION</b>Puncture with a 29G needle causes less injuries and minimal functional changes of the spinal cord, which can serve as a new means for studying spinal neurotoxicity of local anesthetics.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Traumatismos de la Médula Espinal
/
Ratas Sprague-Dawley
/
Recuperación de la Función
/
Modelos Animales de Enfermedad
/
Toxicidad
/
Fenómenos Electrofisiológicos
/
Anestésicos Locales
/
Agujas
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2012
Tipo del documento:
Artículo
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