Bioinformatic analysis of genes related to temporal epilepsy / 南方医科大学学报
Journal of Southern Medical University
;
(12): 180-183, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-267643
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the genes associated with temporal epilepsy and explore the molecular mechanism of epilepsy.</p><p><b>METHODS</b>The microarray data of temporal epilepsy were downloaded from the Gene Expression Omnibus (GEO) database and analyzed by bioinformatics methods using String, KEGG and Panther databases.</p><p><b>RESULTS</b>Of all the 71 differentially expressed genes, 51 were found to encode proteins with interactions; the main biological pathways involved included neuroactive ligand-receptor interactions, MAPK signaling pathway, and calcium signaling pathway etc.</p><p><b>CONCLUSION</b>The pathogenesis of epilepsy involves multiple genes, and investigations of these genes may provide valuable insights into the mechanism of epilepsy.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Expresión Génica
/
Biología Computacional
/
Análisis de Secuencia por Matrices de Oligonucleótidos
/
Sistema de Señalización de MAP Quinasas
/
Perfilación de la Expresión Génica
/
Epilepsia del Lóbulo Temporal
/
Genética
/
Métodos
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2011
Tipo del documento:
Artículo
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