65-month testosterone replacement therapy for androgen deficiency-induced ED: a case report and review of the literature / 中华男科学杂志
National Journal of Andrology
;
(12): 152-155, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-267960
ABSTRACT
<p><b>OBJECTIVE</b>To explore the mechanism of erectile dysfunction (ED) with testosterone deficiency and discuss the feasibility of long-term testosterone replacement therapy (TRT) by observing a case of ED with testosterone deficiency treated by TRT for 65 months.</p><p><b>METHODS</b>We treated an ED patient with testosterone deficiency by TST for 65 months, and evaluated the therapeutic effects by analyzing his IIEF-5 score, dynamic changes in testosterone, PSA, hemoglobin and red blood cell count, and adverse events.</p><p><b>RESULTS</b>The patient was a 46-year-old man, with an IIEF-5 score of 7, baseline serum total testosterone (TT) of 2.79 ng/ml, and no response to phosphodiesterases-5 inhibitors (PDE5i). He was diagnosed with late-onset hypogonadism (LOH) and treated by TRT testosterone undecanoate at 80 mg bid po for the first 2 weeks and then at 40 mg bid po. Two months after medication, the TT level was increased to normal (3.45 ng/ml), and physical fitness and anxiety symptoms were markedly improved, with no significant improvement in sexual function. Then we administered PDE5i on demand in addition, which elevated his IIEF-5 score to > 21. The combined medication of TRT and on-demand PDE5i lasted for 45 months followed by TRT alone for another 18 months. The patient was restored to normal penile erection and sexual satisfaction, with the IIEF-5 score remaining at > 21. Regular follow-up revealed no significant abnormalities in the testosterone level, PSA, and routine blood tests.</p><p><b>CONCLUSION</b>TRT enhances the effect of PDE5i in the treatment of androgen deficiency-induced ED, and long-term TRT is safe and effective for androgen deficiency.</p>
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Testosterona
/
Resultado del Tratamiento
/
Terapia de Reemplazo de Hormonas
/
Usos Terapéuticos
/
Quimioterapia
/
Disfunción Eréctil
/
Andrógenos
Límite:
Humanos
/
Masculino
Idioma:
Chino
Revista:
National Journal of Andrology
Año:
2014
Tipo del documento:
Artículo
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