Protective effects of lidocaine against lung injury after hemorrhagic shock in rabbits / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To study the protective effect of lidocaine against lung injury after hemorrhagic shock in rabbits.</p><p><b>METHODS</b>Eighteen healthy rabbits were randomly divided into 3 groups (n=6), namely lidocaine group (group L), hemorrhagic shock group (group H) and control group (group C). Hemorrhagic shock model was established in rabbits in groups L and H, and the venous blood samples were collected for measurement of plasma malondialdehyde (MDA) and superoxidedismutase (SOD) before phlebotomy (T0), 2 h after hemorrhagic shock (T1) and 2 h after resuscitation (T2). Blood samples were also taken for measurement of MDA and SOD at the same time points in group C. The wet to dry weight ratio of the lung (W/D) was measured at T2.</p><p><b>RESULTS</b>MDA level was significantly lower while SOD level significantly higher in group L than in group H (P<0.05). The W/D ratio in group L was reduced significantly as compared with that in group H (P<0.05).</p><p><b>CONCLUSION</b>Lidocaine can remarkably alleviate lung injury after hemorrhagic shock by inhibiting MDA production and increasing SOD content.</p>