Expression of CCL20 and CXCR4 in epidermal condyloma acuminatum lesions / 南方医科大学学报
Journal of Southern Medical University
; (12): 418-420, 2007.
Article
en Zh
| WPRIM
| ID: wpr-268118
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To detect CCL20 and CXCR4 expressions in epidermis infected with condyloma acuminatum (CA) and normal epidermis and investigate the effect of their expressions on Langerhans cells in CA epidermis.</p><p><b>METHODS</b>Gene expression of CCL20 and CXCR4 in 3 epidermal CA lesions and in 3 normal epidermis specimens were detected using Affymetrix oligonucleotide microarrays HG-U 133A 2.0, and the protein levels of CCL20 and CXCR4 in these specimens were measured by Western blotting.</p><p><b>RESULTS</b>Microarray analysis revealed markedly down-regulated mRNA expressions of CCL20 and CXCR4 in the 3 epidermal CA lesions as compared with those in the normal specimens. Western blot analysis showed that the protein expressions of CCL20 and CXCR4 in the CA lesions were significantly lower than those in normal epidermis.</p><p><b>CONCLUSION</b>The protein and mRNA expressions of CCL20 and CXCR4 are markedly down-regulated in epidermal CA lesions, which may contribute to decreased number and backflow disturbance of Langerhans cells in these lesions.</p>
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Patología
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ARN Mensajero
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Condiloma Acuminado
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Regulación hacia Abajo
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Regulación de la Expresión Génica
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Western Blotting
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Receptores CXCR4
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Análisis de Secuencia por Matrices de Oligonucleótidos
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Epidermis
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Quimiocina CCL20
Límite:
Adult
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Humans
Idioma:
Zh
Revista:
Journal of Southern Medical University
Año:
2007
Tipo del documento:
Article