Design, synthesis and activity evaluation of novel matrix metalloproteinases inhibitors based on the structure of enzyme / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1271-1281, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-268192
ABSTRACT
A novel inhibitor series for matrix metalloproteinases (MMPs) were designed and synthesized. Using succinate and malonate as zinc binding groups and long hydrophobic substituents to bind with S1' pockets, the compounds showed micromolar inhibition and selectivity for MMP-2 over others. And we found a better activity compound. It is a chance to find a better precursor of MMP-2 inhibitors with activity and bioavailability by further optimization of compounds.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Relación Estructura-Actividad
/
Diseño de Fármacos
/
Estructura Molecular
/
Química
/
Metaloproteinasas de la Matriz
/
Inhibidores Enzimáticos
/
Inhibidores de la Metaloproteinasa de la Matriz
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2007
Tipo del documento:
Artículo
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