Potential role of microRNAs in human diseases and the exploration on design of small molecule agents / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1115-1121, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-268220
ABSTRACT
MicroRNAs (miRNAs) are endogenous noncoding RNAs, about 22 nucleotides in length, that mediate post-transcriptional gene modulation by annealing to inexactly complementary sequences in the 3'-untranslated regions of target mRNAs. miRNA alterations are involved in the initiation and progression of human diseases. miRNA-expression profiling of human diseases has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. Recent evidence has suggested miRNAs as viable therapeutic targets for a wide range of human diseases. Several approaches were performed, the experimental examination of these techniques and the resultant findings not only indicate feasibility of interfering miRNA action in a gene-specific fashion but also may provide a new research tool for studying function of miRNAs. The new approaches also have the potential of becoming alternative gene therapy strategies.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Terapéutica
/
ARN Mensajero
/
Diseño de Fármacos
/
Terapia Genética
/
Regulación de la Expresión Génica
/
Perfilación de la Expresión Génica
/
Silenciador del Gen
/
MicroARNs
/
Genética
/
Cardiopatías
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2007
Tipo del documento:
Artículo
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