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Novel mutations of cardiac troponin T in Chinese patients with hypertrophic cardiomyopathy / 中华心血管病杂志
Chinese Journal of Cardiology ; (12): 909-914, 2011.
Artículo en Chino | WPRIM | ID: wpr-268287
ABSTRACT
<p><b>OBJECTIVE</b>To screen the cardiac troponin T (TNNT2) mutations in Chinese patients with hypertrophic cardiomyopathy (HCM) and to analyze the potential link between the genotype and the phenotype.</p><p><b>METHODS</b>Clinical features of 100 probands with HCM and some family members were evaluated, 200 unrelated normal subjects served as control. The exons and flanking introns of TNNT2 were amplified with PCR and direct sequencing was used to screen TNNT2 mutations/polymorphisms.</p><p><b>RESULTS</b>Two novel missense mutations were detected in 2 HCM patients R92W and R286H. These 2 mutations were not found in 200 non-HCM controls. A five-basepair insertion/deletion polymorphism in intron 3 of TNNT2 was identified in this HCM cohort but was not related to the phenotype.</p><p><b>CONCLUSIONS</b>Two missense mutations, R92W and R286H, were found in 2/100 patients with HCM, TNNT 2 mutation is relatively low in Chinese patients with HCM.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Linaje / Fenotipo / Polimorfismo Genético / Cardiomiopatía Hipertrófica / Estudios de Casos y Controles / Exones / Troponina T / Mutación Missense / Pueblo Asiatico / Genética Tipo de estudio: Estudio observacional Límite: Humanos Idioma: Chino Revista: Chinese Journal of Cardiology Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Linaje / Fenotipo / Polimorfismo Genético / Cardiomiopatía Hipertrófica / Estudios de Casos y Controles / Exones / Troponina T / Mutación Missense / Pueblo Asiatico / Genética Tipo de estudio: Estudio observacional Límite: Humanos Idioma: Chino Revista: Chinese Journal of Cardiology Año: 2011 Tipo del documento: Artículo