Study on the value of exogenous bFGF in the treatment of brain injury / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 131-135, 2000.
Artículo
en Inglés
| WPRIM
| ID: wpr-268523
ABSTRACT
OBJECTIVE:
To investigate the relation betwe en necrosis and apoptosis in the hippocampus of exogenous bFGF on this process.METHODS:
With Marmarou's method we produced a severe diffuse brain injury and studied the changes in the hippocampus by adapting a modified T dT-mediated dUTP-biotin nick end labeling (TUNEL) method. At the same time we observed the effect of exogenous bFGF on neuronal necrosis and apoptosis.RESULTS:
We found that together with cell necrosis there was an increase in the number of apoptotic neurons in the hippocampus CA2-3 sectors a s early as 4 h after injury, with numbers reaching a maximum at 7 d. Exogenous b FGF resulted in a definite reduction in the amount of necrosis and apoptosis.CONCLUSIONS:
Neuronal necrosis and apoptosis occur in combinati on after brain injury and that one of the causes may be the insufficience expres sion of the bFGF gene in the hippocampus after severe injury. Exogenous bFGF and similar substance may prove clinically useful after brain injury by reducing ce ll necrosis and apoptosis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Inglés
Revista:
Chinese Journal of Traumatology
Año:
2000
Tipo del documento:
Artículo
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