Synthesis and antibacterial activity of N-(aroylalkyl) ciprofloxacin / 药学学报
Acta Pharmaceutica Sinica
;
(12): 854-857, 2007.
Artículo
en Chino
| WPRIM
| ID: wpr-268566
ABSTRACT
In order to obtain the drugs with broader antibacterial spectrum, better antibacterial effect and less side-effect, modifications with lipid solublity group at the position of piperazinyl of ciprofloxacin 13C NMR, ESI-MS and elemental analysis. The lipid solublility of the new compounds was better than that of ciprofloxacin. The results of antibacterial activity in vitro showed that most of the target compounds possessed relatively high inhibiting activity on Escherichia coli and Pseudomonas aeruginosa. The antibacterial activity of the target compound 3d was higher than that of ciprofloxacin against Escherichia coli.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Pseudomonas aeruginosa
/
Ciprofloxacina
/
Pruebas de Sensibilidad Microbiana
/
Química
/
Escherichia coli
/
Antibacterianos
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2007
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS