Application of multiple tumor markers' s protein chip in the green program of the elderly / 中华流行病学杂志

ABSTRACT

Objective To evaluate the application of the multiple tumor markers' s protein chip (C12 chip) in the screen program of the elderly. Methods The C12 chip included alpha-fetoprotein (AFP) , neuron-specific enolase (NSE) , prostate special antigen (PSA) , frce-PSA(f-PSA), carcinoembryonic antigen ( CEA ), carbohydrate antigen 125 (CA 125 ), carbohydrate antigen 153 (CA153) , carbohydrate antigen 199 (CA199) , carbohydrate antigen 242 (CA242) , human chorionic gonagotropin-bcta ( β-HCG), human growth hormone (HGH) and fcrritin. The sera of the 399 healthy elderly under the screening program and 1791 adults were detected by the C12 chip.Definition of positive was set as one or more tumor markers higher than or equal to the reference value. Results The positive rates of AFP, PSA, f-PSA, CEA, CA125, CA153 and CA199 between the elderly group and the adult group were significantly different (P＜0.05). The normal test value of AFP, PSA, f-PSA, CEA, CA 125, CA 199, CA242 and ferritin between the elderly group and the adult group were significantly different (P＜ 0.05 ). Conclusion AFP, PSA, f-PSA, CEA, CA 125, CA 153and CA199 of the C12 chip were useful in the screening program of the elderly to discover the sign of tumor at an early stage.