Relationship between tight junction proteins and Helicobacter pylori-associated gastric diseases / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 242-247, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-269498
ABSTRACT
Helicobacter pylori (Hp) infection is an important cause of chronic gastritis and peptic ulcer, but their pathogenesis is unclear. The role of gastric mucosal barrier dysfunction induced by impaired structure and function of tight junction in the pathogenesis of Hp-associated gastric diseases has received considerable attention in recent years. Tight junction is composed of a variety of proteins and molecules, including 3 integral membrane proteins (occludin, claudins, and junctional adhesion molecules) and a cytoplasmic protein (zonula occludens). This paper mainly describes the composition and function of various tight junction proteins, changes in tight junction protein function induced by Hp infection and their relationship with the incidence of gastric diseases, and the significance of enhancing the tight junction protein function in the prevention and treatment of Hp-associated gastric diseases.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Gastropatías
/
Neoplasias Gástricas
/
Virulencia
/
Química
/
Helicobacter pylori
/
Infecciones por Helicobacter
/
Estrés Oxidativo
/
Proteínas de Uniones Estrechas
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2014
Tipo del documento:
Artículo
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