MicroRNAs, an active and versatile group in cancers / 国际口腔科学杂志·英文版
International Journal of Oral Science
;
(4): 165-175, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-269662
ABSTRACT
microRNAs (miRNAs) are a class of non-coding RNAs that function as endogenous triggers of the RNA interference pathway. Studies have shown that thousands of human protein-coding genes are regulated by miRNAs, indicating that miRNAs are master regulators of many important biological processes, such as cancer development. miRNAs frequently have deregulated expression in many types of human cancers, and play critical roles in tumorigenesis, which functions either as tumor suppressors or as oncogenes. Recent studies have shown that miRNAs are highly related with cancer progression, including initiating, growth, apoptosis, invasion, and metastasis. Furthermore, miRNAs are shown to be responsible for the cancer-related inflammation, anti-cancer drug resistance, and regulation of cancer stem cells. Therefore, miRNAs have generated great interest as a novel strategy in cancer diagnosis and therapy. Here we review the versatile roles of miRNAs in cancers and their potential applications for diagnosis, prognosis, and treatment as biomarkers.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oncogenes
/
Fisiología
/
Células Madre Neoplásicas
/
Biomarcadores de Tumor
/
Regulación Neoplásica de la Expresión Génica
/
Genes Supresores de Tumor
/
Resistencia a Antineoplásicos
/
MicroARNs
/
Técnicas de Silenciamiento del Gen
/
Transición Epitelial-Mesenquimal
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
International Journal of Oral Science
Año:
2011
Tipo del documento:
Artículo
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