Effect of childhood adiposity on long-term risks of carotid atherosclerosis and arterial stiffness in adulthood / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 28-33, 2016.
Artículo
en Chino
| WPRIM
| ID: wpr-269975
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of childhood excessive adiposity on long-term risk of adult carotid atherosclerosis and arterial stiffness.</p><p><b>METHODS</b>At baseline, in 1987, by using stratified cluster sampling design, 3 198 healthy children aged 6-18 were recruited from six primary schools and six middle schools from three districts (Chaoyang, Xicheng, and Haidian) in Beijing, with blood pressure, weight, height and left scapular skinfold thickness (LSSF) measured. From April 2010 to July 2012, 1 225 subjects were followed from childhood to adulthood. Questionnaire, biochemistry parameters, carotid-femoral pulse wave velocity (cfPWV), and carotid intima media thickness (cIMT) were measured at follow-up. Based on weight statuses in childhood and adulthood, subjects were classified into four groups (persistent non-overweight from childhood to adulthood, overweight in childhood but non-overweight in adulthood, non-overweight in childhood but overweight in adulthood, persistent overweight from childhood to adulthood). Multiple logistic regression model was used to analyze the association between weight statuses changing from childhood to adulthood and adult high cfPWV and high cIMT.</p><p><b>RESULTS</b>The prevalence of overweight (including obesity) at adulthood was 52.2% (639). Males had higher prevalence of smoking (62.5%(422/675) vs 29.4%(160/550), χ(2)=133.21, P<0.001), drinking (52.1%(353/675) vs 26.1%(140/550), χ(2)=87.13, P<0.001), overweight (including obesity) (69.3% (468/675) vs 31.1% (171/550), χ(2)=182.18, P< 0.001) than females. With adjusting for gender, age, and length of follow-up, the risk of high cfPWV and high cIMT increased by 26% and 58% for 1 units increase in BMI, and by 30% and 36% for 1 units increase in LSSF. Compared to subjects with persistent non-overweight from childhood to adulthood, subjects with overweight in childhood but non-overweight in adulthood had similar risks of high cfPWV (OR=1.59, 95%CI 0.77-3.30)and high cIMT (OR=1.47, 95%CI0.65-3.31). The risks of high cfPWV and high cIMT increased among subjects with non-overweight in childhood but overweight in adulthood (OR=1.92, 95%CI1.37-2.68; OR=3.69, 95% CI2.61- 5.23) and among subjects with persistent overweight from childhood to adulthood (OR=2.53, 95%CI1.70-3.76; OR=5.37, 95%CI3.62-7.97).</p><p><b>CONCLUSIONS</b>We concluded that a overweight children changed to a healthy weight adult, the risks of adult subclinical atherosclerosis and arterial stiffness would not be increased.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Presión Sanguínea
/
Enfermedades de las Arterias Carótidas
/
Índice de Masa Corporal
/
Epidemiología
/
Factores de Riesgo
/
Aterosclerosis
/
Sobrepeso
/
Adiposidad
/
Grosor Intima-Media Carotídeo
/
Rigidez Vascular
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adolescente
/
Adulto
/
Niño
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Chino
Revista:
Chinese Journal of Preventive Medicine
Año:
2016
Tipo del documento:
Artículo
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