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HLA-DRB1 allelic polymorphism in children with juvenile idiopathic arthritis / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 333-337, 2010.
Artículo en Chino | WPRIM | ID: wpr-270347
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the predisposing alleles of HLA-DRB1 genes in Han children with juvenile idiopathic arthritis (JIA) from Guangdong Province, China.</p><p><b>METHODS</b>Polymerase chain reaction-specific sequence primers (PCR-SSP) method was used to type HLA-DRB1 subregions in 94 Han children with JIA and 226 Han healthy controls.</p><p><b>RESULTS</b>The frequency of HLA-DRB1*08 allele in the JIA group was significantly higher than that in the control group (P=0.0014, OR=2.26), in contrast, the frequency of HLA-DRB1*12 allele was significantly lower than that in the control group (P=0.032, OR=0.55). It was found that in children with So-JIA subset (P=0.023, OR=2.25) and polyarthritis JIA subset (P=0.034, OR=2.81), the allele HLA-DRB1*08 was expressed most commonly. The allele HLA-DRB1*15 was expressed in a lower frequency in children with So-JIA subset (P=0.049, OR=0.413) and oligoarthritis subset (P=0.045, OR=0.16) compared with that in the control group.</p><p><b>CONCLUSIONS</b>HLA-DRB1*08 may be the susceptible allele of JIA, while HLA-DRB1*12 may be the protective allele of JIA in Han children from Guangdong Province. HLA-DRB1*08 is the susceptible allele of So-JIA and polyarthrits. HLA-DRB1*15 is the protective allele for systemic JIA and oligoarthritis.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Polimorfismo Genético / Artritis Juvenil / Antígenos HLA-DR / Predisposición Genética a la Enfermedad / Alelos / Cadenas HLA-DRB1 / Genética Límite: Adolescente / Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Contemporary Pediatrics Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Polimorfismo Genético / Artritis Juvenil / Antígenos HLA-DR / Predisposición Genética a la Enfermedad / Alelos / Cadenas HLA-DRB1 / Genética Límite: Adolescente / Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Chino Revista: Chinese Journal of Contemporary Pediatrics Año: 2010 Tipo del documento: Artículo