Changes in urotensin-II expression in airway remodelling in asthmatic rats / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 287-289, 2010.
Article
en Zh
| WPRIM
| ID: wpr-270362
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the role of urotension-II in serum and bronchoalveolar lavage fluid (BALF) in the process of airway remodelling in asthmatic rats.</p><p><b>METHODS</b>Thirty-two male Sprague-Dawley (SD) rats were randomly divided into normal control and 2-week, 4-week and 8-week asthmatic groups (OVA inhalation of 2, 4 and 8 weeks respectively). Rats were sensitized and challenged by OVA to establish a model of asthma. The bronchial wall thickness and the airway smooth muscle thickness were measured by image analysis system. The urotension-II contents in serum and BALF were determined using ELISA.</p><p><b>RESULTS</b>The bronchial wall thickness and the airway smooth muscle thickness in the three asthmatic groups significantly increased compared with those in the normal control group (P<0.01). The urotension-II contents in serum and BALF in the three asthmatic groups also increased significantly compared with those in the normal control group (P<0.01). The urotension-II contents in serum and BALF in the 8-week asthmatic group were the highest, followed by the 4-week and the 2-week asthmatic groups (P<0.01). BALF urotension-II contents were positively correlated with the bronchial wall thickness and the airway smooth muscle thickness as well as serum U-II contents in the four groups.</p><p><b>CONCLUSIONS</b>The urotension-II contents in serum and BALF in the process of airway remodeling increase in asthmatic rats. The changes in serum and BALF urotension-II contents may be associated with airway remodeling in asthmatic rats.</p>
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Índice:
WPRIM
Asunto principal:
Patología
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Asma
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Urotensinas
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Sangre
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Bronquios
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Líquido del Lavado Bronquioalveolar
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Química
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Ratas Sprague-Dawley
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Remodelación de las Vías Aéreas (Respiratorias)
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Metabolismo
Límite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2010
Tipo del documento:
Article