Anti-nociceptive effect in mice of thillai flavonoid rutin / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 295-299, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-270602
ABSTRACT
We investigated the anti-nociceptive effect of Excoecaria agallocha (E.agallocha) against chemically and thermally induced nociception, Albino mice received a dose of 10, 15, 20, or 25 mg/kg of alkaline chloroform fraction (Alk-CF) of E.agallocha by oral administration. Compared with controls, Alk-CF decreased the writhing numbers (P<0.01) in a dose dependent manner. Further we determined that, Alk-CF contained, a potent compared to control, also potent anti-nociceptive agent that acted via opioid receptors and using HPLC, identified this compound as Rutin. Docking simulation demonstrated that Rutin interacted strongly with cyclooxygenase, forming a number of specific hydrogen bonds. In conclusion we have identified peripheral and central anti-nociceptive activities of E.agallocha that involve opioid receptor, and in which the active compound is Rutin.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Dolor
/
Rutina
/
Extractos Vegetales
/
Química
/
Euphorbiaceae
/
Usos Terapéuticos
/
Evaluación Preclínica de Medicamentos
/
Quimioterapia
/
Analgésicos
/
Fitoterapia
Límite:
Animales
Idioma:
Inglés
Revista:
Biomedical and Environmental Sciences
Año:
2014
Tipo del documento:
Artículo
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