Change of plasma pro-inflammatory cytokines levels in patients with hemorrhagic fever with renal syndrome / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 607-609, 2008.
Artículo
en Chino
| WPRIM
| ID: wpr-270639
ABSTRACT
<p><b>OBJECTIVE</b>To observe the changes of the plasma pro-inflammatory cytokines levels in patients with hemorrhagic fever with renal syndrome (HFRS).</p><p><b>METHODS</b>Enzyme-linked immunosorbent assay (ELISA) was performed to detect the plasma pro-inflammatory cytokines levels of 22 HFRS patients (9 mild cases and 13 moderate cases) 1, 4, and 12 weeks after they were diagnosed. Sixteen healthy blood donors were recruited as control group.</p><p><b>RESULTS</b>The levels of interleukin (IL)-1beta, IL-6, IL-10, tumor necrosis factor (TNF)-alpha, and IL-8 in HFRS patients were significantly higher than those in control group 1 week after they were diagnosed (all P < 0.01). The levels of IL-6 and TNF-alpha in HFRS patients returned to the normal levels four weeks after the diagnosis, while those of IL-1beta, IL-8, and IL-10 remained significantly higher than those in control group 12 weeks after the diagnosis (all P < 0.01). The IL-8 and IL-10 levels in mild HFRS patients were significantly higher than those in moderate HFRS patients at the same period (all P < 0.05).</p><p><b>CONCLUSION</b>Abnormal expressions and secretion of pro-inflammatory cytokines occurs during the disease course of HFRS.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sangre
/
Citocinas
/
Mediadores de Inflamación
/
Alergia e Inmunología
/
Fiebre Hemorrágica con Síndrome Renal
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2008
Tipo del documento:
Artículo
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