Plasma transforming growth factor-beta1 levels in patients with erectile dysfunction / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 349-353, 2004.
Article
en En
| WPRIM
| ID: wpr-270885
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>AIM</b>To evaluate the plasma TGF-beta1 level in erectile dysfunction (ED) patients of various causes.</p><p><b>METHODS</b>Sixty-two patients with ED and 26 potent men were subjected to the study. Based on multidisciplinary work-ups, including medical history, physical examinations, blood tests with lipid profile and hormones, penile duplex Doppler ultrasonogram and neurophysiological tests, causes for ED were classified as psychogenic (n=15), neurogenic (n=16) and vasculogenic (n=31). The plasma TGF-beta1 level was measured by the ELISA method.</p><p><b>RESULTS</b>The plasma TGF-beta1 level was significantly increased in the ED group (6.7+/-4.9 ng/mL), compared to the control (4.0 +/-2.1 ng/mL) (P<0.01). In the ED groups, there was a significant increase in the vasculogenic group (9.0 +/-5.5 ng/mL), compared to the psychogenic (3.8 +/-1.8 ng/mL) and neurogenic groups (4.8+/-3.2 ng/mL) (P<0.01). Of the vascular risk factors, both the smoking (7.5 +/-4.7 ng/mL) and dyslipidemia groups (7.4+/-4.4 ng/mL) showed significantly increased plasma TGF-beta1 levels, compared to the non-smokers (5.5+/-2.8 ng/mL), and those without dyslipidemia (4.8+/-2.8 ng/mL) (P<0.05).</p><p><b>CONCLUSION</b>Vascular risk factors are associated with an elevated plasma TGF-beta1 level, which may contribute to cavernous fibrosis and ED.</p>
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Índice:
WPRIM
Asunto principal:
Pene
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Arteriosclerosis
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Psicología
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Sangre
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Ensayo de Inmunoadsorción Enzimática
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Diagnóstico por Imagen
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Fumar
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Factores de Riesgo
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Factor de Crecimiento Transformador beta
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Ultrasonografía
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
Idioma:
En
Revista:
Asian Journal of Andrology
Año:
2004
Tipo del documento:
Article