Poly(AT) polymorphism in DNA repair gene XPC and lung cancer risk / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 555-557, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-271082
ABSTRACT
<p><b>OBJECTIVE</b>It has been shown that suboptimal DNA repair capacity is associated with cancer risk and that a poly(AT) polymorphism in XPC gene (XPC PAT) may influence DNA capacity. This study was designed to assess the relationship between XPC PAT polymorphism and susceptibility to lung cancer in the Chinese population.</p><p><b>METHODS</b>XPC genotypes were determined by PCR methods in 509 healthy controls and 597 patients with lung cancer. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariate logistic regression model.</p><p><b>RESULTS</b>Genotype frequencies of XPC PAT among controls were 37.9% (PAT-/-), 49.7% (PAT+/-) and 12.4% (PAT+/+), respectively. They were not significantly different from those among lung cancer patients (42.1%, 46.7% and 11.2%, respectively; P = 0.37). Individuals carrying XPC PAT+/+ genotype were not at increased risk for lung cancer as compared with those with PAT+/- or PAT-/- genotype (adjusted OR, 0.8; 95% CI, 0.55 approximately 1.16). No interaction between XPC genotype and smoking was observed.</p><p><b>CONCLUSION</b>Our findings indicate that the XPC PAT polymorphism may not be associated with risk of lung cancer in the Chinese population.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
ADN
/
Riesgo
/
Proteínas de Unión al ADN
/
Reparación del ADN
/
Genética
/
Genotipo
/
Neoplasias Pulmonares
/
Metabolismo
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Oncology
Año:
2003
Tipo del documento:
Artículo
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