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Resolution of alpha-cyclohexyl mandelic acid enantiomers by enantioselective extraction in separation system containing tartaric esters and beta-cyclodextrin / 药学学报
Acta Pharmaceutica Sinica ; (12): 376-379, 2006.
Artículo en Chino | WPRIM | ID: wpr-271423
ABSTRACT
<p><b>AIM</b>To establish a resolution method for alpha-cyclohexyl mandelic acid enantiomers by enantioselective extraction and to observe the effects of all kinds of tartaric esters, pH, the concentration of D-tartaric esters and beta-cyclodextrin on the enantioselectivity.</p><p><b>METHODS</b>Resolution of alpha-cyclohexyl mandelic acid enantiomers by enantioselective extraction with tartaric esters and beta-cyclodextrin has been studied.</p><p><b>RESULTS</b>The distribution behavior of alpha-cyclohexyl mandelic acid enantiomers in the separation system was studied. The effects of all kinds of tartaric esters, pH, the concentration of D-tartaric esters and beta-cyclodextrin on the enantioselectivity has been examined in the two-phase.</p><p><b>CONCLUSION</b>Results showed that the complex formed by D-iso-butyl-D-tartaric ester with R enantiomer is stabler than that with S enantiomer. With the increase of pH, the partition coefficient and separation factor decreased. The concentration of beta-cyclodextrin and D-tartaric ester had visible effect on the enantioselectivity.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Estereoisomerismo / Tartratos / Química / Beta-Ciclodextrinas / Ésteres / Ácidos Mandélicos Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Estereoisomerismo / Tartratos / Química / Beta-Ciclodextrinas / Ésteres / Ácidos Mandélicos Idioma: Chino Revista: Acta Pharmaceutica Sinica Año: 2006 Tipo del documento: Artículo