Impact of intravenous nutrition on plasma free amino acid spectrum and immune function for patients with sepsis / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the impact of intravenous nutrition on plasma free amino acid spectrum and immune function for patients with sepsis.</p><p><b>METHODS</b>Forty severe sepsis patients were divided into two groups Group B (amino acids + glucose + fat emulsion) and Group A (glucose + fat emulsion), 20 healthy individuals were enrolled as control group. The concentration of free amino acid and immune globulin were determined after 3 days.</p><p><b>RESULTS</b>In Group A, the levels of valine, leucine, isoleucine, alanine, serine, glutamic acid, histidine, proline and glycine were decreased; while the levels of threonine, cysteine, the ratio of phenylalanine and tyrosine (Phe/Tyr) were higher than those in control group. Meanwhile, peripheral blood IgM, complement C3 and C4 were decreased. In group B, all amino acid levels were improved, but the level of alanine, serine, glutamic acid, histidine and proline still lower than those in control group. Similarly, the levels of IgM, complement C3 and C4 in group B were increased.</p><p><b>CONCLUSION</b>Intravenous nutrition can support the basal requirement of amino acid and improve the immune function of patients with sepsis.</p>