Effect of dan-shen, san-qi of different proportion on platelet aggregation and adhesion in normal rabbits / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To observe the effect of the crude extracts of Dan-shen root and San-qi of different proportion on platelet aggregation and adhesion in normal rabbits.</p><p><b>METHOD</b>With rabbits, ig. (4d, exsanguinated via carotid artery, percentage of platelet aggregation and adhesion was measured.</p><p><b>RESULT AND CONCLUSION</b>Aspirin (4.4 mg/Kg) could markedly inhibit platelet aggregation and adhesion in normal rabbit. The proportions of Dan-shen root/San-qi (100, 101, 103, 106, 110) could markedly inhibit platelet aggregation, among which 103 was the best. San-qi alone had little effect on aggregation. The proportions of Dan-shen root/San-qi (103, 106, 010) could markedly inhibit platelet adhesion, among which 010 was the best, and the proportions(100, 101, 110) had little effect.</p>