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Cardiovascular risk profile of patients with glycogen storage disease type I / 中华心血管病杂志
Chinese Journal of Cardiology ; (12): 508-511, 2011.
Artículo en Chino | WPRIM | ID: wpr-272210
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the cardiovascular risk profile in patients with glycogen storage disease (GSD) type I.</p><p><b>METHOD</b>The clinical information of 62 patients with GSD type I who admitted to Peking Union Medical Hospital were reviewed and the cardiovascular risk profile was analyzed.</p><p><b>RESULTS</b>The age of the patient cohort was (8.4 ± 6.9) years and the ratio of male vs. female was 3626. The median disease duration was (6.7 ± 6.2) years and treatment duration was (38.3 ± 35.2) months. The rate of abnormal change in electrocardiogram and echocardiography was 17.7% and 24.2%, respectively. The serum concentration of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and uric acid in patient before and after treatment were (6.18 ± 2.47) mmol/L vs. (5.61 ± 1.84) mmol/L (P = 0.020), (11.17 ± 9.85) mmol/L vs. (6.81 ± 5.97) mmol/L (P = 0.010), (2.55 ± 1.27) mmol/L vs. (2.78 ± 1.07) mmol/L (P = 0.617), (0.98 ± 0.37) mmol/L vs. (0.96 ± 0.23) mmol/L (P = 0.005), (526.53 ± 127.09) µmol/L vs. (490.78 ± 129.79) µmol/L (P = 0.977), respectively. The high-sensitivity C-reactive protein levels tended to be higher after therapy compared before treatment (2.33 ± 3.30) mg/L vs. (3.35 ± 3.39) mg/L, P = 0.431.</p><p><b>CONCLUSION</b>Patients with GSD I are associated with an increased risk for cardiovascular disease.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Triglicéridos / Sangre / Proteína C-Reactiva / Diagnóstico por Imagen / Enfermedades Cardiovasculares / Enfermedad del Almacenamiento de Glucógeno Tipo I / Factores de Riesgo / Ultrasonografía / HDL-Colesterol / Lipoproteínas LDL Tipo de estudio: Estudio diagnóstico / Estudio de etiología / Factores de riesgo Límite: Adolescente / Niño / Child, preschool / Femenino / Humanos / Lactante / Masculino Idioma: Chino Revista: Chinese Journal of Cardiology Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Triglicéridos / Sangre / Proteína C-Reactiva / Diagnóstico por Imagen / Enfermedades Cardiovasculares / Enfermedad del Almacenamiento de Glucógeno Tipo I / Factores de Riesgo / Ultrasonografía / HDL-Colesterol / Lipoproteínas LDL Tipo de estudio: Estudio diagnóstico / Estudio de etiología / Factores de riesgo Límite: Adolescente / Niño / Child, preschool / Femenino / Humanos / Lactante / Masculino Idioma: Chino Revista: Chinese Journal of Cardiology Año: 2011 Tipo del documento: Artículo