Clinical features of drug-induced liver injury in children / 中国当代儿科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the clinical features of drug-induced liver injury in children.</p><p><b>METHODS</b>The clinical data of the hospitalized children with drug-induced liver injury over 5 years were retrospectively reviewed.</p><p><b>RESULTS</b>Of 641 cases of hospitalized children with liver injury, there were 64 cases (10%) of drug induced liver injury. Hepatocellular injury was the most common type of drug-induced liver injury (81%). The major drugs causing drug-induced liver injury included chemotherapy drugs, antibiotics and anti-tuberculosis drugs. Rash (16%), gastrointestinal reaction (15%), fever (14%) and liver intumescence (12%) were common clinical symptoms. A part of patients with drug-induced liver injury (11%) had no symptoms and signs.</p><p><b>CONCLUSIONS</b>Drug-induced liver injury is one of the common causes of liver damage in hospitalized children. Some children with drug-induced liver injury have no symptoms and signs. Hepatocellular injury is a major type of drug-induced liver injury in children, resulting less severe liver damage.</p>