Risk factors for infection with extended-spectrum beta-lactamase-producing strains in children / 中国当代儿科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the risk factors for infection with extended-spectrum beta-lactamase (ESBL) producing strains in children.</p><p><b>METHODS</b>The clinical data of 242 pediatric in-patients with lower respiratory tract infections from February 2009 to January 2011 were retrospectively analyzed. The risk factors of ESBL-producing strain infections were investigated using univariate analysis and multivariate logistic regression analysis.</p><p><b>RESULTS</b>Univariate analysis showed that six factors were related with ESBL-producing strain infections repeated sucking of phlegm (OR 2.279, P<0.01), tracheal intubation(OR 3.101, P<0.01), administration of the third generation cephalosporin for more than three days (OR 3.628, P<0.01), admission to the pediatric intensive care unit (PICU) (OR 2.378, P<0.01), indwelling of nasogastric tube (OR 2.460, P<0.01), prophylactic use of antibiotics (OR 1.747, P<0.05). Multivariate logistic regression showed that the application of the third-generation cephalosporin for more than three days (OR 5.672, P<0.01), repeated sucking of phlegm (OR 3.917, P<0.01), tracheal intubation (OR 3.717, P<0.01), indwelling of nasogastric tube (OR 2.961, P<0.01), and admission to PICU (OR 3.237, P<0.01) were the independent risk factors for the infections.</p><p><b>CONCLUSIONS</b>The infections of ESBL-producing strains are caused by many factors, among which the application of the third-generation cephalosporin for more than three days, invasive operations, and admission to PICU are the independent risk factors.</p>