Effects of Rbl on action potentials and force of contraction in guinea pig ventricular papillary muscles / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 366-368, 2003.
Artículo
en Chino
| WPRIM
| ID: wpr-272852
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effects of Rbl on action potentials and force of contraction in guinea pig ventricular papillary muscles.</p><p><b>METHOD</b>The ventricular papillary muscles of guinea pig were isolated regularly and immersed with Tyrode, s solution. The effects of Rbl (purified saponins of panaxnotoginseng) on the action potentials (AP), the slow action potentials and the force of contraction (FC) of the muscles were studied. The AP and FC were measured synchronously.</p><p><b>RESULT</b>Rbl shortened the duration of AP, including APD2O and APD90, and reduced the FC(n = 5, P < 0.01), but didn't affect the rest potential (RP), the amplitude of action potential (APA), overshot (OS) and maximal upstrok velocity (Vmax). Rbl also decreased the APA of slow action potential, but quinidine had no such effects.</p><p><b>CONCLUSION</b>Rbl may be a channel blocker.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Músculos Papilares
/
Farmacología
/
Fisiología
/
Potenciales de Acción
/
Medicamentos Herbarios Chinos
/
Bloqueadores de los Canales de Calcio
/
Química
/
Ginsenósidos
/
Panax
/
Cobayas
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2003
Tipo del documento:
Artículo
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