Effects of regulatory peptides on adhesion of eosinophil to bronchial epithelial cells / 生理学报
Acta Physiologica Sinica
; (6): 43-46, 2002.
Article
en Zh
| WPRIM
| ID: wpr-272986
Biblioteca responsable:
WPRO
ABSTRACT
To explore the roles of regulatory peptides in the process of various anaphylactic inflammation of the airway, we observed the influence of four peptides, i.e., vasoactive intestinal peptide (VIP), epidermal growth factor (EGF), endothelin-1 (ET-1), and calcitonin gene-related peptide (CGRP), on the adhesion of eosinophil (EOS) to unstimulated and O(3)-stressed bronchial epithelial cells (BEC). From the experiments we observed that VIP and EGF decreased EOS adherence to O(3)-stressed BEC and downregulated airway inflammation; ET-1 and CGRP increased the adhesion of EOS to BEC in the inflammatory process; and CGRP aggravated O(3)-stressed reactions. The effects of ET-1 and CGRP were inhibited by W(7)and H(7). Anti-ICAM-1 antibody inhibited the adhesion of EOS to BEC, which brings to light that EOS adherence to BEC may be related to the expression of ICAM-1 of BEC.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Farmacología
/
Fisiología
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Bronquios
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Péptido Intestinal Vasoactivo
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Adhesión Celular
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Células Cultivadas
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Molécula 1 de Adhesión Intercelular
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Endotelina-1
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Biología Celular
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Alergia e Inmunología
Límite:
Animals
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Año:
2002
Tipo del documento:
Article