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Correlations between papillary thyroid cancer and peripheral blood levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2 / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 1925-1929, 2013.
Artículo en Inglés | WPRIM | ID: wpr-273070
ABSTRACT
<p><b>BACKGROUND</b>The relationship between the presence of metalloproteinases and thyroid cancer remains unknown, and many controversies still exist in this field. The objective of this study was to investigate the correlations between papillary thyroid cancer and peripheral blood levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2.</p><p><b>METHODS</b>The correlations were studied by detecting the levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2 by enzyme-linked immunosorbant assay and reverse-transcription polymerase chain reaction in the peripheral blood of 30 patients with papillary thyroid carcinoma, 27 patients with benign thyroid disease, and 25 healthy volunteers.</p><p><b>RESULTS</b>The levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2 in the peripheral blood of patients with papillary thyroid carcinoma were significantly higher than those in the peripheral blood of patients with benign thyroid disease and healthy volunteers (P < 0.05). However, there were no significant differences between patients with benign thyroid disease and healthy volunteers (P > 0.05). The accuracy of detection by both enzyme-linked immunosorbant assay and reverse-transcription polymerase chain reaction in the papillary thyroid cancer group was 83.33%.</p><p><b>CONCLUSIONS</b>The levels of matrix metalloproteinase-2, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and tissue inhibitor of metalloproteinase-2 in the peripheral blood are helpful in identifying thyroid carcinoma and aid in preoperative assessment.</p>
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Sangre / Ensayo de Inmunoadsorción Enzimática / Neoplasias de la Tiroides / Inhibidor Tisular de Metaloproteinasa-1 / Inhibidor Tisular de Metaloproteinasa-2 / Reacción en Cadena de la Polimerasa de Transcriptasa Inversa / Metaloproteinasa 2 de la Matriz / Metaloproteinasa 9 de la Matriz Límite: Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Inglés Revista: Chinese Medical Journal Año: 2013 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Patología / Sangre / Ensayo de Inmunoadsorción Enzimática / Neoplasias de la Tiroides / Inhibidor Tisular de Metaloproteinasa-1 / Inhibidor Tisular de Metaloproteinasa-2 / Reacción en Cadena de la Polimerasa de Transcriptasa Inversa / Metaloproteinasa 2 de la Matriz / Metaloproteinasa 9 de la Matriz Límite: Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Inglés Revista: Chinese Medical Journal Año: 2013 Tipo del documento: Artículo