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Inhibitory Effect of Antibody to alphavbeta5 in Corneal Angiogenesis
Journal of the Korean Ophthalmological Society ; : 1594-1599, 2001.
Artículo en Coreano | WPRIM | ID: wpr-27310
ABSTRACT

PURPOSE:

This study investigated the importance of alphavbeta5 function during vascular endothelial growth factor (VEGF) induced corneal angiogenesis by examining the effects of antibody to alphavbeta5 that blocks alphav 5-mediated cell adhesion to vitronectin.

METHODS:

A hydrogel disk containing 500 ng of VEGF was implanted into the superior corneal stroma of each of sixteen New Zealand white rabbit eyes. Each eye also received a second hydrogel disk placed adjacent to the first, randomized to contain either 40 g of antibody to alphavbeta5 (n=8) or phosphate-buffered saline (PBS)(n=8). Both disks were positioned 1.2 mm apart from the superior limbus. Eyes were examined daily under a stereomicroscope by two observers and assigned an angiogenesis score based on number and length of new blood vessels.

RESULTS:

On days 3 through 7 postimplantation, angiogenesis scores were significantly lower in eyes treated with antibody to alphavbeta5 (averaged score=16.33) as compared to eyes treated with PBS (averaged score=26.52)(P<0.05, Wilcoxon signed rank test).

CONCLUSIONS:

In a rabbit corneal micropocket assay, antibody to alphavbeta5 inhibits corneal angiogenesis induced by VEGF. Substances that target the integrin alphavbeta5 subunit may have therapeutic potential in disorders characterized by ocular neovascularization.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Vasos Sanguíneos / Adhesión Celular / Neovascularización de la Córnea / Vitronectina / Sustancia Propia / Hidrogeles / Factor A de Crecimiento Endotelial Vascular / Nueva Zelanda Tipo de estudio: Ensayo Clínico Controlado País/Región como asunto: Oceanía Idioma: Coreano Revista: Journal of the Korean Ophthalmological Society Año: 2001 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Vasos Sanguíneos / Adhesión Celular / Neovascularización de la Córnea / Vitronectina / Sustancia Propia / Hidrogeles / Factor A de Crecimiento Endotelial Vascular / Nueva Zelanda Tipo de estudio: Ensayo Clínico Controlado País/Región como asunto: Oceanía Idioma: Coreano Revista: Journal of the Korean Ophthalmological Society Año: 2001 Tipo del documento: Artículo