Expression of receptor activator of NF-kappa B ligand and osteoprotegerin protein in the giant cell lesions of jaw / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 294-297, 2005.
Artículo
en Chino
| WPRIM
| ID: wpr-273233
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of RANKL and OPG protein in the giant cell lesions of jaw and to study the mechanism of this lesion.</p><p><b>METHODS</b>RANKL and OPG were detected by immunohistochemistry (SP) in 24 paraffin-embedded and 2 frozen specimens of central giant cell lesion of jaw.</p><p><b>RESULTS</b>RANKL signals were strongly positive in the vascular epithelial cells. They also could be found in fibrous stroma, bone matrix, and stromal spindle cells, even in some cytomembrane of multinucleated giant cells. OPG was detected in multinucleated giant cells and a fraction of round mononuclear cells.</p><p><b>CONCLUSIONS</b>Active vascular epithelial cells are contributed to the formation of multinucleated giant cells through regulating RANKL, and RANKL could play its role by paracrine and autocrine, which might be inhibited by OPG.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteoclastos
/
Patología
/
Enfermedades Maxilomandibulares
/
Células Gigantes
/
Ligando RANK
/
Osteoprotegerina
/
Metabolismo
Límite:
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Stomatology
Año:
2005
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS