Annexin A5 gene polymorphism (-1C/T) and the susceptibility to pneumoconiosis in coal works / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 246-249, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-273512
ABSTRACT
<p><b>OBJECTIVE</b>To explore the role of -1C/T single nucleotide polymorphism within Annexin A5 gene in the genetic susceptibility to coal worker's pneumoconiosis (CWP).</p><p><b>METHODS</b>Four hundred and seventy CWP Han chinese patients and 428 Han chinese controls were enclosed in present case-control study. All subjects were exposed to coal dusts. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the -1C/T SNP in Annexin A5 gene for all subjects. The relationship between the -1C/T SNP in Annexin A5 gene and CWP was analyzed.</p><p><b>RESULTS</b>CT/TT genotype in -1C/T SNP was associated with a significantly decreased risk of CWP, as compared with the CC genotype among subgroups exposed to coal dusts for ≥ 27 years (adjusted OR = 0.65, 95%CI 0.44 - 0.98, P = 0.039) and patients with CWP at stage II (adjusted OR = 0.55, 95%CI 0.34 - 0.90, P = 0.028).</p><p><b>CONCLUSION</b>The results of present study suggest that the Annexin A5 -1C/T polymorphism may be involved in the development of CWP in Han Chinese coal miners.</p>
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Estudios de Casos y Controles
/
Anexina A5
/
Predisposición Genética a la Enfermedad
/
Polimorfismo de Nucleótido Simple
/
Pueblo Asiatico
/
Antracosis
/
Frecuencia de los Genes
/
Genética
/
Genotipo
Tipo de estudio:
Estudio observacional
/
Factores de riesgo
Límite:
Anciano
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Año:
2012
Tipo del documento:
Artículo
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